NOVEL MEDICAL TARGETS
Nephrilin™ is a designed inhibitor of mammalian target of rapamycin
complex-2 (mTORC2), an evolutionarily conserved complex present in all
mammalian cells. Unlike its well-known counterpart, Raptor-containing
mTORC1, Rictor-containing mTORC2 is rapamycin-insensitive and believed
to play a role in cell shape, cell motility and responses to stress —
primarily by phosphorylating AGC kinases such as AKT, PKC and SGK.
NOVEL TRANSPORTER PLATFORM
The MBD transporter is a short peptide derived from human IGFBP-3. When
covalently attached to other peptides, large proteins or small nucleic
acids, the MBD rapidly transports its cargo into cytoplasmic and
nuclear compartments of targeted cells.The MBD appears to differentiate
between normal cells and cells under stress, targeting the latter. This
makes the transporter particularly useful for targeting cells in a
variety of diseased states.
NOVEL PSYCHOLOGICAL TOOLS
The eSAIL is a fisrt-in-kind instrument for segmenting human
populations in novel ways. The technology has been proven to match
individuals with books that they are more likely to enjoy.
NOVEL WAYS OF MANAGING KNOWLEDGE
The "retro" is a simple, original and effective way of distilling
expert knowledge for a general medical audience. Expert Journal(TM) is
structured to provide this type of content fully leveraging modern
trends such as mobile access and social networking.